Fig. 2: Association between MRS glutamate metabolite signal in the dACC voxel, a node in the Salience Network at baseline and the degree of improvement in PANSS symptom domains from baseline to 12 weeks when taking risperidone. | Neuropsychopharmacology

Fig. 2: Association between MRS glutamate metabolite signal in the dACC voxel, a node in the Salience Network at baseline and the degree of improvement in PANSS symptom domains from baseline to 12 weeks when taking risperidone.

From: Glutamatergic basis of antipsychotic response in first-episode psychosis: a dual voxel study of the anterior cingulate cortex

Fig. 2

Degree of improvement was measured by subtracting follow-up PANSS scores from baseline scores. Larger positive values indicate a greater improvement in symptoms, while negative values along y axis indicate a worsening over time. Glu: glutamate; Glx: glutamate + glutamine; PANSS: PANSS positive and negative syndrome scale for schizophrenia. The relationships between both dACC Glu and Glx at baseline and degree of improvement in PANSS negative symptoms over 12 weeks were significant, P < 0.05.

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