Fig. 7: HFD abrogates the protection of HMGA1 depletion on Hmga1â–³IEC mice from CRC tumorigenesis. | Nature Communications

Fig. 7: HFD abrogates the protection of HMGA1 depletion on Hmga1â–³IEC mice from CRC tumorigenesis.

From: High mobility group A1 (HMGA1) promotes the tumorigenesis of colorectal cancer by increasing lipid synthesis

Fig. 7

Hmga1flox/flox and Hmga1△IEC mice were treated with high fat diet (HFD) and AOM/DSS for the induction of CRC. a, d Schematic diagram of the induction. b, e Representative images of colorectum in the mice. c, f The number and size of tumors in the entire colorectum in each mouse were measured. g, i HE staining of the colorectum (CRC) from mice treated with control diet (CD), CD and AOM/DSS, HFD, and HFD and AOM/DSS (Scale bar = 20 μm. Representative images from 3 independent experiments). The percentage of LGD, HGD, and carcinoma was determined. LGD: low-grade dysplasia; HGD: high-grade dysplasia. h, j Representative images of IHC staining of Ki67 in murine colorectum (Scale bar = 20 μm). Data are presented as mean ± SD. Statistical significance was determined by two-tailed unpaired t-test (c, f, h, j). n = 12. Source data are provided as a Source Data file.

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