Fig. 4: Comparison of PET-CT analysis by two independent readers (18 scans), N = 9.

Correlation (Left column) and Bland-Altman (Right column). Dashed lines in Bland-Altman plots represent Limits of Agreement (LoA). A two-sided test was applied to all tests of statistical significance. TLG (A) Spearman’s r > 0.99, P < 0.0001, and (B) Bias = 10.7, 95% LoA: −49.9, 71.21; SUVmax (C) Spearman’s r = 0.98, P < 0.0001, and (D) Bias = −0.12, 95% LoA: −1.17, 0.93; TMV in cm3 (E) Spearman’s r = 0.99, P < 0.0001), and (F) Bias = 5.80, 95% LoA: −26.4, 38.0; Number of PET-CT avid lesions (G) Spearman’s r = 0.72, P = 0.0008, and (H) Bias = −1.67, 95% LoA: −10.61, 7.3. Single outlier of disagreement in Bland-Altman plots of TMV (3D) and TLG (3 F) corresponds to the highest readings of TMV and TLG by both readers (means of 850.8 cm3 and 3436.1 respectively). Source data are provided as a Source Data file.