Fig. 2: Plasma concentration of HE072 versus time profile. | Nature Communications

Fig. 2: Plasma concentration of HE072 versus time profile.

From: Intravenous liposomal irinotecan in metastatic triple-negative breast cancer after ≥ 2 prior lines of chemotherapy: a phase Ib study

Fig. 2

Mean (SD) plasma concentration-time curve of free irinotecan (a), total irinotecan (b) and SN-38 (c) after the treatment with HE072 50 mg/m2 (n = 12) and 70 mg/m2 (n = 107). Over the dose range of 50–70 mg/m2, the Cmax and AUC of total irinotecan, free irinotecan, and SN-38 increases with dose (n = 119). Source data are provided as a Source Data file.

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