Fig. 8: Working model of cargo loading to polycystin ciliary EVs of C. elegans.

A single genetic perturbation leads to a drastic change in EV cargo composition. Compare WT polycystin EVs (a) with EVs of the lov-1 and pkd-2 mutants (b). Refer to the Discussion, Limitations of Study, and Supplementary Figs. 11 and 12 legend sections for a detailed description.