Fig. 2: Fatty-acid oxidation is enriched in the neovascular unit in mouse proliferative retinopathy. | Nature Communications

Fig. 2: Fatty-acid oxidation is enriched in the neovascular unit in mouse proliferative retinopathy.

From: Metabolic reprogramming of the neovascular niche promotes regenerative angiogenesis in proliferative retinopathy

Fig. 2

a Schematic representation of the oxygen-induced retinopathy (OIR) mouse model of proliferative retinopathy. b Heatmap of fatty acylcarnitine metabolites measured in human vitreous and mouse retinas of control (human n = 4, mouse n = 4) and proliferative retinopathy samples (human n = 7, mouse n = 4). c UMAP of single-cell RNAseq from normoxic (n = 6, 21305 cells) and OIR (n = 8, 17814 cells) retinas taken during the neovascularisation period (P14-P17) representing the 11 retinal cell types identified by graph-based clustering of normalized RNA count (GEO accession number GSE150703). d Ridge plot of GSVA score for REACTOME mitochondrial beta-oxidation of saturated fatty acids pathway for OIR cell types at P14 and P17. e Dot plot illustrating the expression levels of genes from the REACTOME pathway related to mitochondrial beta-oxidation of saturated fatty acids across OIR cell types at P14 and P17. f Graphical representation of the vascular unit during the neovascular phase of OIR.

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