Extended Data Fig. 6: Accumulation of 11,12-EET boosts tissue regeneration in vivo.
From: Gasdermin D-mediated metabolic crosstalk promotes tissue repair
a, Immunoblots and quantification (n = 3) of EPHX2 expression in peritoneal macrophages. b, Mean CSA (n = 5), related to Fig. 4c. c,d, Muscle strength (n = 3) (c) and weight (n = 6) (d) of TA muscles from Ephx2f/f and Ephx2CKO mice at 14 dpi. e, Expression of Myod and Myog mRNA levels in Ephx2f/f and Ephx2CKO muscle at indicated dpi (n = 4). f,g, The frequency distribution (n = 3, GsdmdCKOEphx2CKO and GsdmdCKOEphx2Het; n = 6, GsdmdHetEphx2CKO and GsdmdHetEphx2Het) of myofiber CSA at 14 dpi, related to Fig. 4j. h,i, Representative images of Ephx2f/f and Ephx2CKO TA muscle cross-sections (h) and the frequency distribution (n = 4, DMSO; n = 6, DSF) (i) of myofiber CSA at 14 dpi with or without DSF treatment. A representative of at least two independent experiments is shown. Unpaired two-tailed t test applied for (a-d); Two-way ANOVA applied for (e-g,i) with Šidák correction. Mean ± SEM. Abbreviation: DSF, disulfiram (MCE, HY-B0240).
