Extended Data Fig. 2: Single-cell data analysis of muscles from Gsdmdf/f and GsdmdCKO mice.
From: Gasdermin D-mediated metabolic crosstalk promotes tissue repair
a,b, Heatmap (a) and featureplot (b) showing the expression of signature markers of each cell type. c,d, UMAP plot of dynamics of cell populations during regeneration. e-g, CytoTRACE score of each state of MuSCs (e,f). Dotplot of the enrichment score of indicated gene sets calculated by AddModuleScore, related to Fig. 2d (g). h, Immunoblots and grayscale statistics of the PI3K-AKT-mTOR and MAPK signaling pathways downstream of FGF-FGFR in TA muscles from Gsdmdf/f and GsdmdCKO mice subjected to CTX-induced injury. A representative (h) of at least two independent experiments is shown.
