Extended Data Fig. 10: In-vivo validation of MT isoform expression from an unrelated autism NRXN1+/− patient.
From: Phenotypic complexities of rare heterozygous neurexin-1 deletions
(a) Schematic of novel NRXN1 autism patient, and GOF therapeutic targeting pipeline, with (b) schematic of the NRXN1α isoform structures, with each row representing a unique NRXN1α isoform and each column representing a NRXN1 exon. The colored isoforms (navy, wildtype; peach, patient-specific) are spliced into the transcript while the blank exons are spliced out. The schematic in panel a was created using BioRender. Fernando, M. (2025) https://BioRender.com/f78d262. (c) The abundance of each NRXN1α isoform by sample.
