Extended Data Fig. 10: Viral knock-down of Drd1 or Drd2 in vSub – validation and additional anxiety-related behaviors.
From: Dopamine D1–D2 signalling in hippocampus arbitrates approach and avoidance
a, Experimental schematic. Data are obtained from the same mice as in Fig. 5i–l (n = 11 shDrd1, n = 11 shDrd2, n = 14 GFP male mice). b, Drd1 mRNA expression. LM-ANOVA: virus F2,32 = 3.60 p = 0.0389; followed by FDR-adjusted post-hoc tests. c, Drd2 mRNA expression. LM-ANOVA: virus F2,32 = 7.14 p = 0.0027; followed by FDR-adjusted post-hoc tests. d, Total number of OA entries in EPM. LM-ANOVA: virus F2,33 = 0.12 p = 0.8839. e, Total locomotor activity in OFT. LM-ANOVA: virus F2,33 = 0.67 p = 0.5190. f, Time spent in OFT center zone. LM-ANOVA: virus F2,33 = 1.66 p = 0.2049; followed by FDR-adjusted post-hoc tests. g, Latency to the first feeding bout during NSF testing. LM-ANOVA: virus F2,33 = 3.33 p = 0.0482; followed by FDR-adjusted post-hoc tests. Data represented as mean ± sem.
