Extended Data Fig. 7: Plots of relevant metabolic traits in individuals free of diabetes who are carriers and non-carriers of the LEP rare variant or the variants with intermediate penetrance (VIPs) in Monogenic Diabetes genes. | Nature Genetics

Extended Data Fig. 7: Plots of relevant metabolic traits in individuals free of diabetes who are carriers and non-carriers of the LEP rare variant or the variants with intermediate penetrance (VIPs) in Monogenic Diabetes genes.

From: Rare variant analyses in 51,256 type 2 diabetes cases and 370,487 controls reveal the pathogenicity spectrum of monogenic diabetes genes

Extended Data Fig. 7

a-b, Effect of LEP, rs147287548, chr7:128323039 on the levels of apolipoprotein A (a) and HDL cholesterol (b). c-m, Effect of HNF4A, chr20:44413714, p.Arg114Trp on the levels of apolipoprotein a (c), apolipoprotein b (d), aspartate aminotransferase (e), glucose (f), HDL cholesterol (g), lipoprotein A (h), triglycerides (i), total cholesterol (j), LDL cholesterol (k), sex hormone binding globulin (l) and urea (m). n-o, Effect of GCK, chr7:44145170, p.Val455Glu on the levels of glucose (n) and hba1c (o). Data from heterozygous carriers and from homozygous non-carriers of the variants. Individuals from UKB were considered for this analysis. Each violin plot represents the distribution of the metabolic trait values by genotype, with the width of the violin indicating the density of the data. The inner box plots indicate the group median (central line), first and third quartiles (bounds of box), and 1.5x interquartile range (whiskers).

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