Fig. 1: Precision PSA project workflow and composition. | Nature Genetics

Fig. 1: Precision PSA project workflow and composition.

From: Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups

Fig. 1

The discovery GWAS analysis revealed 318 genome-wide significant (P < 5 × 10−8, two-sided test) variants associated with PSA, of which 184 were novel. The joint analysis (consisting of the discovery and replication cohorts) revealed 447 genome-wide significant variants associated with PSA, of which an additional 111 were novel. Both discovery and joint GWAS results were used to develop PRSs for PSA, which were then evaluated in GERA (when out of sample), PCPT and SELECT. Sig, significant; SNP, single-nucleotide polymorphism.

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