Extended Data Fig. 7: Differential molecular changes between progressive and regressive lesions.

Visualization of differential changes across the genome. A, shows all identified differentially methylated regions (DMRs) (hypermethylated regions in yellow, hypomethylated in blue) alongside a similar analysis comparing cancer and control samples from The Cancer Genome Atlas. We observe that 58% of DMRs identified in our progressive vs regressive analysis are also identified in cancer vs control. B, shows copy number changes across the genome in regressive CIS, progressive CIS and TCGA cancer samples. We observe congruency of copy number change, suggesting similar processes in the two cohorts.