Extended Data Fig. 8: rs10487505 is a significant eQTL in the GTEx portal.
From: Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity
a,b, The GTEx portal (https://gtexportal.org/) was queried for rs10487505, indicating a single eQTL (a) that impacts expression of IMPDH1 in thyroid (b) (n = 103 reference homozygotes, n = 204 heterozygotes, n = 92 alternative homozygotes). Box plots depict the interquartile range (IQR) and mean, and whiskers depict minimum and maximum values (1.5 times IQR). P value was calculated with a linear regression model. The normalized effect size (NES) of the eQTL is defined as the slope of the linear regression.
