Extended Data Fig. 2: Tumor and nontumor regions contain a highly diverse polyclonal TCR repertoire. | Nature Medicine

Extended Data Fig. 2: Tumor and nontumor regions contain a highly diverse polyclonal TCR repertoire.

From: Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer

Extended Data Fig. 2

a–c, Graphs depicting the total number of TCR α-chain and β-chain segments sequenced (left), the number of unique TCR sequences detected (middle) and the correlation between the total number of TCR α-chain and β-chain segments sequenced (right) in multiregion tumors (n = 220) (a), nontumor lung (n = 64) (b) and PBMCs (n = 56) (c). Spearman’s rank correlation P values are shown. d, The relationship between the total number of TCRs in each region (expressed as log2) and the transcriptional score for a set of genes specifically expressed in T cells (see Methods). The Spearman’s rank correlation coefficient and P value are shown; n = 99.

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