Extended Data Fig. 8: TNFα/NFκB, EGF and HBO1 (KAT7) Gene Scores. | Nature Medicine

Extended Data Fig. 8: TNFα/NFκB, EGF and HBO1 (KAT7) Gene Scores.

From: Motixafortide and G-CSF to mobilize hematopoietic stem cells for autologous transplantation in multiple myeloma: a randomized phase 3 trial

Extended Data Fig. 8

For three different pathways a list of genes was curated, derived from GSEA and the literature, to evaluate changes in expression of related pathways (Methods). Each Gene Score dot plot shows the average gene expression score indicated by heat map color and overlayed with the numerical score. Dot size indicates the percentage of cells expressing each transcriptional program. Each plot is also separated by mobilization regimen (left axis); by multiple myeloma (M) and healthy allo-donor cohorts (H) (right axis); and by the HSC1-6 or MLP population of interest (bottom axis).

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