Fig. 2: Multi-ancestry GWAS of PSA levels.
From: Genetically adjusted PSA levels for prostate cancer screening
a, Manhattan plot depicting the results of the GWAS meta-analysis of PSA levels in 95,768 men without prostate cancer. The genome-wide significance threshold of P < 5 × 10−8 is indicated by the dotted black line. Index variants within known PSA-associated loci are annotated with the corresponding cytoband. Novel findings are highlighted in yellow. b, Circular dendogram shows the nearest gene(s) for novel PSA-associated variants. Genome-wide significant (P < 5 × 10−8) index variants were selected using LD-based clumping (LD r2 < 0.01 within ±10-Mb windows). All GWAS P values are two-sided and derived from a fixed-effects inverse-variance-weighted meta-analysis using METAL.
