Extended Data Fig. 2: Impact of correction for PSA-related selection bias on genetic associations with prostate cancer.
From: Genetically adjusted PSA levels for prostate cancer screening
Associations with prostate cancer for 128 PSA-associated index variants were obtained from the PRACTICAL GWAS by Conti et al.32 PSA index variants were selected from the multi-ancestry GWAS meta-analysis using clumping and thresholding (P < 5 × 10−8, linkage disequilibrium r2 < 0.01). a, GWAS effect sizes for prostate cancer (βPrCa) are aligned to the PSA-increasing allele. Bias-adjusted effect sizes (βadj) are denoted by triangles. b, Two-sided GWAS p-values for prostate cancer (PPrCa) were derived from an inverse-variance-weighted fixed-effects meta-analysis. Two-sided bias-adjusted p-values (Padj), denoted by triangles, were calculated from a chi-squared test statistic based on βadj and corresponding standard errors. Genome-wide significance threshold (P < 5 × 10−8) is indicated by the dotted line.
