Extended Data Fig. 3: Ancestry composition of validation cohorts.
From: Genetically adjusted PSA levels for prostate cancer screening
Admixture plots visualizing genetic ancestry proportions for participants within population clusters in a, Prostate Cancer Prevention Trial (PCPT) and b, Selenium and Vitamin E Cancer Prevention Trial (SELECT). Both cohorts were excluded from the PSA GWAS used for polygenic score development. For each individual, the proportion of African (AFR), European (EUR), and East Asian (EAS) genetic ancestry is shown. Single-ancestry clusters include individuals with ancestry scores ≥0.80 in one ancestry group. Admixed ancestry clusters AFR/EUR and EAS/EUR include individuals with ancestry proportions >0.20 and <0.80. For analyses of prostate cancer risk in SELECT, AFR and AFR/EUR and EAS and EAS/EUR were combined into pooled African ancestry (n = 2,936) and pooled East Asian ancestry (n = 578), respectively.
