Fig. 1: Summary of main analyses.
From: Sex differences in brain protein expression and disease
We investigated sex differences in protein expression and its genetic regulation using brain proteomic and genetic data. Next, we compared effects of sex on gene expression and its genetic regulation at both the mRNA and protein levels using genetic and brain transcriptomic and proteomic data. Subsequently, we examined the intersection between psychiatric and neurologic causal genes and genes with sex-biased protein expression or sb-pQTLs. Finally, we integrated sex-stratified GWAS with pQTLs to identify sex-specific causal genes in psychiatric and neurologic disorders. TMT, tandem mass tag.
