Extended Data Fig. 4: Imputation of TFV-DP concentration from plasma TFV quantifiability.

Measurements of intraerythrocytic TFV-DP among HPTN 082 participants with quantifiable or unquantifiable plasma TFV using the quantification threshold of each trial (see Extended Data Table 2). Plots are based on a total of N = 1083 samples, which are divided into positive and negative depending on the quantification threshold. For FEMPrEP and partners PrEP, the total is only 1081 because for two samples the quantification threshold could not be evaluated due to missing data. Width = frequency, white dot = median, black rectangle = interquartile range, black line = upper and lower adjacent values.