Extended Data Fig. 2: CAR-NK cell persistence in the peripheral blood (PB) of patients after CAR19/IL-15 NK-cell infusion. | Nature Medicine

Extended Data Fig. 2: CAR-NK cell persistence in the peripheral blood (PB) of patients after CAR19/IL-15 NK-cell infusion.

From: Safety, efficacy and determinants of response of allogeneic CD19-specific CAR-NK cells in CD19+ B cell tumors: a phase 1/2 trial

Extended Data Fig. 2

(a) Measurements of CAR-NK cells in PB samples (CAR copy number) by quantitative polymerase-chain-reaction (qPCR) in overall responders (ORs, blue; n = 18 patients) vs. non-responders (NRs, black; n = 19 patients) after treatment with CAR19/IL-15 NK cells. Each dot represents a measurement for one patient at one time point. Measurements for individual patients are connected using dashed lines. The solid lines represent the mean values for each group. (b) Measurements of CAR copy number by qPCR in PB samples of patients according to the degree of match at HLA-A, HLA-B and HLA-DR loci between the cord donor and the patient; HLA match 0/6 (n = 5 patients), HLA match 1-3/6 (n = 13 patients), HLA match 4/6 (n = 19 patients). Data are shown as median + 95% CI. P-values were determined by mixed-effects model with Geisser-Greenhouse correction in panel a.

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