Extended Data Fig. 8: Cross-trait sex-specific colocalization of BP-associated loci with CVDs. | Nature Medicine

Extended Data Fig. 8: Cross-trait sex-specific colocalization of BP-associated loci with CVDs.

From: Sex-specific genetic architecture of blood pressure

Extended Data Fig. 8

Loci identified in the analyses of SBP (a), DBP (b) and PP (c) with colocalization posterior probability >0.50 in only one sex and the differences in colocalization posterior probability between females and males >0.5, in a ±250 Kb window. The closest gene to the index SNP is shown for each region. Heatmap values reflect the differences (ranging from −1 to 1) in the posterior probabilities from the colocalization of each CVD trait and female-only BP associations, and the colocalization of each CVD trait and male-only BP associations. Blue and red colors represent regions with male-biased and female-biased colocalization, respectively. AS: any stroke. AIS: any ischemic stroke. LAS: large artery stroke. CES: cardioembolic stroke. SVS: small vessel stroke. ICA: intracranial aneurysms. SAH: subarachnoid hemorrhage. uIA: unruptured intracranial aneurysms; HTN: hypertension. CAD: Coronary artery disease. MI: myocardial infarction. FMD: fibromuscular dysplasia. PE: preeclampsia. HF: heart failure; AF: atrial fibrillation; AA: aortic aneurysm; AA.TAA: thoracic aortic aneurysm; AortaD.aa: thoracic aorta dimensions, ascending aortic diameter; AortaD.da: thoracic aorta dimensions, descending aortic diameter; SCAD: spontaneous coronary artery dissection.

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