Extended Data Fig. 4: TFBS enrichment at sex-specific BP-associated loci. | Nature Medicine

Extended Data Fig. 4: TFBS enrichment at sex-specific BP-associated loci.

From: Sex-specific genetic architecture of blood pressure

Extended Data Fig. 4

(a) Beeswarm plots show the top 10 ranked TFs based on TFBS enrichment tests of autosomal sex-specific BP loci using LOLA’s reference ChIP-Seq datasets (268 TFs out of 4166 datasets). LD-pruned GWAS loci associated with BP in females only (SBP: 86 loci, DBP: 183 loci, PP: 140 loci), males only (SBP: 37 loci, DBP: 44 loci, PP: 60 loci), and their combinations were tested using Unibind in a ±500 Kb window, comparing genomic locations of all arterial expressed genes as background. Each plot displays the distribution of enrichment test results for each TF. P values are unadjusted. The heatmap presents each of top 10 enriched TFs, scaling from 0 to 1 (highest enrichment), from these 12 separate tests of TFBS enrichment. (b) Beeswarm plots show the top 10 ranked TFs based on differential TFBS enrichment analyses within a 500Kb window, comparing sex-specific and non-sex-specific BP loci. P values are unadjusted.

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