Extended Data Fig. 3: Knockdown of Tom and Bsg affects larval and adult locomotion. | Nature Medicine

Extended Data Fig. 3: Knockdown of Tom and Bsg affects larval and adult locomotion.

From: Exome sequencing reveals genetic heterogeneity and clinically actionable findings in children with cerebral palsy

Extended Data Fig. 3

a. Relative crawling speed of a single 3rd instar larval was measured as the number of squares (sqr) crossed during test for each genotype as indicated (P = 0.019 and 0.0002 for Bsg knockdown). n = 15 larvae for each case. b. Adult climbing locomotion was measured as the time for 50% flies to reach the threshold line (8 cm from the bottom) for different genotypes as indicated (P = 0.0062 and 0.0010 for Tom knockdown; P = 0.0022 and 0.0043 for Bsg knockdown). n = 6 flies for each case. The differences were compared using a statistical method called the Log-rank (Mantel-Cox) Test. ‘*’ means P < 0.05, ‘**’ means P < 0.01, and ‘***’ means P < 0.001. Data are presented as mean values +/− SEM.

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