Extended Data Fig. 5: The KEGG pathway of the P/LP-variants-related genes and VUS-related genes.

a showed the KEGG pathway using P/ LP-variants-related genes (n = 218). And b is the KEGG pathway using VUS-related genes (n = 299). The size of the circle represents the number of genes in the pathway. Hypergeometric test was used in the pathway enrichment analysis and Benjamin and Hochberg method was applied to deal with the multiple correction problem. The color is the corrected p-value, and the darker the color, the more significant the p-value.