Extended Data Fig. 4: Locus-specific estimates of differentiation between pairs of African populations. | Nature Medicine

Extended Data Fig. 4: Locus-specific estimates of differentiation between pairs of African populations.

From: High-resolution African HLA resource uncovers HLA-DRB1 expression effects underlying vaccine response

Extended Data Fig. 4

Measures of differentiation between African populations for three class I and five class II HLA genes, determined by defining the HLA alleles at 6-digit (3-field) resolution. Estimates, in GST, are between pairs of populations with the first population represented as the colour of each point, and the second as a shape of the point allowing a determination of the combination of populations through colour and shape. Admixed American populations include ACB: African Caribbean in Barbados (n = 79) and ASW: African Ancestry in Southwest USA (n = 62); BF: Burkina Faso (n = 167); ESN: Esan in Nigeria (n = 99); GWD: Gambian in Western Division, The Gambia – Mandinka (n = 112); LWK: Luhya in Webuye, Kenya (n = 97); MKK: Maasai in Kinyawa, Kenya (n = 166); MSL: Mende in Sierra Leone (n = 84); SA: South Africa (n = 396); UG: Uganda (n = 330); YRI: Yoruba in Ibadan, Nigeria (n = 110).

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