Extended Data Fig. 3: Immune landscape clusters.
a-d, Forest plots displaying HR (centre of error bar), 95%CI (error bar) and two-sided p-values as calculated through either univariate (UVA) or MVA (adjusted for age and IMDC risk group) Cox proportional hazard regression models of whole patients’ cohort and subgroup analysis per treatment type (with n representing number of patients per group), for PFS (a-b) and OS (c-d). P values are not corrected for multiple testing. e, f, Bar chart representing distribution of Fuhrman tumour grade (e) and sarcomatoid differentiation (f) stratified by ILS clusters. Two-sided p-value as calculated by Fisher’s Exact test. g, Co-expression network based on TCGA KIRC and further based on 95 genes associated with worse ORR, PFS and OS. Only spearman correlations with coefficient > 0.7 are shown. Node size represents betweenness.
