Extended Data Fig. 7: Liver immune cells among recurrence groups. | Nature Medicine

Extended Data Fig. 7: Liver immune cells among recurrence groups.

From: Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer

Extended Data Fig. 7

a, Liver biopsies obtained at the time of resection from patients with NED, or distant recurrence (EHM, LiM>6, or LiM<6) were manually scored by a blinded pathologist for lobular inflammation (Kruskal-Wallis test). b-h, Liver biopsies were stained by IHC (b, d) or IF (c, e-h) for different immune cell markers, quantified using ImageJ and compared between the defined PaC recurrence pattern groups (ANOVA and pair-wise t-tests with multiple comparison correction by FDR; only p-values < 0.25 are shown). Mean ± SEM are shown in bar graphs. b, CD45+ cells (n = 22; ANOVA p = 0.161). c, CD11B+ cells (n = 37; ANOVA p = 0.504). d, IBA1+ cells (n = 38; ANOVA p = 0.185). e, CD68+ cells (n = 29; ANOVA p = 0.544). f, CD3+ cells (n = 36; ANOVA p = 0.335). g, CD3+CD8+ cells (n = 36; ANOVA p = 0.289). h, CD3+CD8− cells (n = 36; ANOVA p = 0.420).

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