Extended Data Table 4 Moderation analysis for clinical variables: estimated margins of interaction effect between moderator variable and treatment group, including 96.5% confidence intervals

From: Digital AVATAR therapy for distressing voices in psychosis: the phase 2/3 AVATAR2 trial

  1. AH, auditory hallucinations; AV-BRF, Brief AVATAR therapy; AV-EXT, Extended AVATAR therapy; DSO, Disturbances in self-organization; ITQ, International Trauma Questionnaire; MH, mental health; PSYRATS, Psychotic Symptom Rating Scales; PTSD, Post-Traumatic Stress Disorder; TAU, treatment as usual; VoCC, Voice Characterization Checklist. Time points: 16, 16 weeks after baseline (after-treatment follow-up); 28, 28 weeks after the baseline follow-up. Mixed-effects regression models were used for the analysis, with robust standard error estimation. Two-sided tests were applied, with adjustments for multiple comparisons using a significance level of 0.035 and 96.5% confidence intervals reported. The β coefficients represent the difference in treatment effect estimates attributable to changes between the levels of the moderator, as specified in the ‘Comparison’ column, for each treatment condition shown in the ‘Treatment’ column. Bold denotes P ≤ 0.035.
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