Fig. 3: Vaccine-specific IgG levels in the serum: kinetics and magnitude, and correlation with BM IgG ASC responses. | Nature Medicine

Fig. 3: Vaccine-specific IgG levels in the serum: kinetics and magnitude, and correlation with BM IgG ASC responses.

From: SARS-CoV-2-specific plasma cells are not durably established in the bone marrow long-lived compartment after mRNA vaccination

Fig. 3

a, Kinetics and magnitude of IgG titers from subjects (n = 8) with at least two sequential serum samples (collected before the additional SARS-CoV-2 vaccines). b–d, Serum IgG levels versus BM IgG LLPC, non-LLPC and total ASC responses for Flu (b), Tet (c) and S2P (d) specificities in all examined subjects (n = 19). Sera collected within 5 months of the time of BM aspiration. For b–d, data were generated from eight different SARS-CoV-2-vaccinated subjects and correlations were assessed using simple linear regression analysis performed with GraphPad Prism (GraphPad Software). The exact P values for vaccine-specific LLPCs, non-LLPCs and total ASCs are 0.0043, 0.0196 and 0.0075, respectively (b); <0.0001, 0.91 and <0.0001, respectively (c); and 0.6096, 0.0025 and 0.0008, respectively (d). All serum samples tested at dilutions of 1:1,000–1:100,000 (total IgG) or 1:200–1:16,000 (antigen-specific IgG). For serum total and vaccine-specific IgG standard curves, see Supplementary Fig. 1. For details of subjects and samples, see Table 1.

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