Extended Data Fig. 7: Characterization of pathways differentially methylated at gene promoters and also dysregulated in the proteome within paired patient BM tissue and primary LUAD tumors.
From: Prediction of brain metastasis development with DNA methylation signatures
a, GSEA of pathways differentially methylated at gene promoters in BM samples compared to LUAD including those related to immune function, tissue differentiation and development within the nervous system and other systems, and cell interaction. b, Proteomics analysis in paired primary LUAD and matched BM dataset showing shared pathways between differential proteomics analysis (data in ref. 22) and differential methylation analysis (study data). c, Metaprograms characterized by non-negative matrix factorization for clustering of proteomics data.
