Extended Data Fig. 3: Characterization of pathways differentially methylated at gene promoters and also dysregulated in the proteome within LUAD tumors that developed BM within 5 years or had high methylome-based risk scores.
From: Prediction of brain metastasis development with DNA methylation signatures
a, GSEA of pathways differentially methylated at gene promoters in LUAD that developed BM compared to LUAD without BM throughout 5-years of follow-up. Pathways shown are mainly immune and differentiation and development related as shown with yellow boxes. b, GSEA showing shared pathways of differential proteomics and methylation analyses within the study cohort comparing LUAD that developed BM versus those without BM over 5 years. c, GSEA of shared pathways of differential proteomics and methylation analyses using CPTAC dataset comparing proteomes from LUAD with high versus low methylome-based BM predictor risk scores.
