Fig. 2: Mean percent changes in body weight as measured from randomization (week 0) and from the baseline of the 4-week behavioral treatment run-in (week −4).
a, Mean (±s.e.) percent changes in body weight as measured from randomization to week 24 in the 76 early nonresponders randomized to BT + AOM (phentermine = 15.0 mg d−1) or BT plus placebo. b, Mean (±s.e.) percent changes in body weight as measured from baseline of the 4-week BT run-in in the 76 early nonresponders randomized to BT + AOM or BT + P, as well as changes in the 55 early responders who were not randomized. Weekly values include participants who both completed the BT session and provided a weight measurement. The body weights of all enrolled individuals were captured at the assessments at weeks −4, 0 and 24. The uptick in measured weight at week 24 is likely attributable in whole or in part to the inclusion of individuals whose weights were not consistently captured before week 24. Week 24 intention-to-treat values were obtained from linear mixed model analyses. Modeled estimates for all time points can be found in Extended Data Fig. 2.
