Extended Data Fig. 1: Histological characteristics of broad rim lesions (BRL). | Nature Medicine

Extended Data Fig. 1: Histological characteristics of broad rim lesions (BRL).

From: Broad rim lesions are a new pathological and imaging biomarker for rapid disease progression in multiple sclerosis

Extended Data Fig. 1

Large demyelinated lesion with a sharp border (immunohistochemistry for MBP). b, the lesion is surrounded by a broad rim of HLA-DR positive myeloid cells. c, quantification of myeloid rim size in a subset of MSwRP and MSwSP. d to g, Immunohistochemistry for CD68+ (d), HLA-DR+ (e), IBA1+ (f) myeloid cells as well as TSPO+ myeloid cells and astrocytes (g). h to m, Depiction of iNOS+ (h) and TMEM119+ cells (i), CD3 + T cells (j), CD79a positive B cells (k), GFAP+ astrocytes (l) and TPPP/p25+ oligodendrocytes (m). Scale bars in a and b: 2.5 mm, scale bars in d to g 100 µm, scale bars in h to m 50 µm.

Back to article page