Extended Data Fig. 2: Context-wise expression of PREDICT T1D microRNAs.
From: A microRNA-based dynamic risk score for type 1 diabetes
Relative expression of the 50 PREDICT T1D microRNAs in the circulation of study participants from four contexts (AUS, HKG, IND, DNK). AUS Control n = 209, T1D n = 519; HKG Control n = 118, T1D n = 120; IND Control n = 133, T1D n = 497; DNK siblings of individuals with T1D n = 292, T1D n = 316. Further details of study participants are provided in Supplementary Table 2. The Y-axis presents microRNA transcript abundance (fold-over-detectable) with data for each of the four contexts and all four contexts together (“All Four”) on the X-axis. Each dot in the scatter plot denotes the microRNA expression level for a single individual, with a green colour for Control samples, while a dark red colour for individuals with T1D. For DNK, siblings of individuals with T1D are presented with a lighter red colour. Data presents the geometric mean with 95% CI (solid lines). Significance is calculated using Kruskal-Wallis test with uncorrected Dunn’s multiple comparison. NS= not significant; *=p < 0.05; **=p < 0.01; ***=p < 0.001, ****=p < 0.0001.
