Extended Data Fig. 10: Differences in perivascular cell signaling capacity in the ME and cortex. | Nature Neuroscience

Extended Data Fig. 10: Differences in perivascular cell signaling capacity in the ME and cortex.

From: Characteristics of blood–brain barrier heterogeneity between brain regions revealed by profiling vascular and perivascular cells

Extended Data Fig. 10

(a, b) Bubble plots from CellChat analysis showing ligand-receptor pairs between (b) cortex ECs and pericytes and astrocytes and (c) ME Plvap ECs and astrocytes, tanycytes, pericytes and fibroblasts. ME pericyte data is from the scRNAseq dataset. p-values were calculated by permutation test in the CellChat R package. (c) Overview of ligand-receptor analysis methodology and workflow. (d) EC ligand-receptor interaction scores with pericyte, astrocyte, tanycyte and fibroblast receptors in the ME or cortex with values > 40 and p-values < 0.01. Candidate, ME-enriched ligand-receptor interaction investigated in Fig. 7 is highlighted in blue. Candidate, cortex-enriched ligand-receptor interaction investigated in Fig. 7 is highlighted in red. Uppercase ligand-receptor pairs are from Kumar et al. database. ME pericyte data is from GeoMX spatial transcriptomic profiling.

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