Table 6 Comparative univariate disease-free survival analysis of upper tract urothelial cancer patients according to local and review pathology.
Univariate analysis, disease-free survival | Local pathologist | Review pathologist | ||
|---|---|---|---|---|
HR (95% CI) | p-value | HR (95% CI) | p-value | |
Grade | ||||
 Low grade | 1 |  | 1 |  |
 High grade | 2.364 (1.278, 4.373) | 0.006** | 2.304 (1.485, 3.574) |  < 0.001** |
 Not mentioned | 2.710 (0.600, 12.238) | 0.195 | 4.716 (1.111, 20.016) | 0.035 |
Architecture | ||||
 Papillary | 1 |  | 1 |  |
 Non-papillary | 1.028 (0.670, 1.577) | 0.898 | 1.753 (1.183, 2.599) | 0.005** |
 Mixed | 1.400 (0.902, 2.172) | 0.133 | 1.737 (1.124, 2.684) | 0.013* |
 Not mentioned | 1.083 (0.501, 2.341) | 0.839 | 3.058 (0.750, 12.467) | 0.119 |
Invasiveness | ||||
 Non-invasive | 1 |  | 1 |  |
 Invasive | 1.985 (1.197, 3.294) | 0.008** | 2.416 (1.676, 3.484) |  < 0.001** |
 Not mentioned | 5.718 (0.757, 43.194) | 0.091 | 4.346 (1.047, 18.036) | 0.043* |
Variant histology | ||||
 No | 1 |  | 1 |  |
 Yes | 1.436 (0.842, 2.450) | 0.184 | 1.991 (1.422, 2.789) |  < 0.001** |
pT stage | ||||
 Tis/Ta/T0 | 1 |  | 1 |  |
 T1/T2 | 1.268 (0.741, 2.170) | 0.387 | 1.576 (0.971, 2.557) | 0.065 |
 T3/T4 | 2.656 (1.589, 4.440) |  < 0.001** | 2.956 (2.026, 4.313) |  < 0.001** |
LVI | ||||
 Negative/free | 1 |  | 1 |  |
 Positive | 1.613 (1.122, 2.319) | 0.010* | 2.882 (2.078, 3.997) |  < 0.001** |
 Not mentioned | 2.853 (0.904, 9.003) | 0.074 |  |  |
PNI | ||||
 Negative/free | 1 |  | 1 |  |
 Positive | 3.896 (2.403, 6.317) |  < 0.001** | 3.081 (2.054, 4.619) |  < 0.001** |
 Not mentioned | 2.569 (1.713, 3.854) |  < 0.001** |  |  |
Surgical margin | ||||
 Free | 1 |  | 1 |  |
 Not free | 2.896 (1.461, 5.739) | 0.002** | 3.064 (1.938, 4.843) |  < 0.001** |
 Not mentioned | 4.364 (1.075, 17.716) | 0.039* | 4.398 (1.078, 17.945) | 0.039* |
