Table 4 Risk of CVD mortality associated with positive screen for cancer after excluding screening-detected cancers.
Groups | Overall | Without previous CVD | With previous CVD | |||
---|---|---|---|---|---|---|
CVD mortality | Adjusted | CVD mortality | Adjusted | CVD mortality | Adjusted | |
/ Total | HR (95%CI)a | / Total | HR (95%CI)a | / Total | HR (95%CI)a | |
Control arm | 8788 / 74,008 | Ref.b | 3626 / 45,288 | Ref.b | 5162 / 28,720 | Ref.b |
 Male | 5319 / 36,197 | Ref.c | 2092 / 21,145 | Ref.c | 3227 / 15,052 | Ref.c |
 Female | 3469 / 37,811 | Ref.d | 1534 / 24,143 | Ref.d | 1935 / 13,668 | Ref.d |
Screening arm | 8366 / 69,247 | 0.996 (0.966–1.026)b | 3359 / 42,474 | 0.964 (0.920–1.011)b | 5007 / 26,773 | 1.019 (0.980–1.059)b |
 No screen | 865 / 4776 | 1.436 (1.338–1.540) b | 281 / 2436 | 1.431 (1.266–1.616) b | 584 / 2340 | 1.445 (1.326–1.575) b |
 Negative screening | 337 / 3642 | 0.924 (0.828–1.030)b | 143 / 2378 | 0.885 (0.748–1.046)b | 194 / 1264 | 0.952 (0.825–1.099)b |
 Positive screens | 7164 / 60,829 | 0.963 (0.933–0.993) b | 2935 / 37,660 | 0.939 (0.894–0.986) b | 4229 / 23,169 | 0.980 (0.941–1.021)b |
  Number of positive screens | ||||||
   ≤ 2 positive screens | 3504 / 32,468 | 0.933 (0.897–0.970) b | 1494 / 20,523 | 0.919 (0.865–0.976) b | 2010 / 11,945 | 0.945 (0.898–0.995) b |
   > 2 positive screens | 3660 / 28,361 | 0.993 (0.955–1.032)b | 1441 / 17,137 | 0.959 (0.902–1.019)b | 2219 / 11,224 | 1.015 (0.966–1.067)b |
  Type of occasional positive screening (≤ 2 positive screens) | ||||||
   Positive X-ray | 1879 / 14,204 | 1.101 (1.047–1.157) b | 744 / 8547 | 1.057 (0.976–1.143)b | 1135 / 5657 | 1.132 (1.061–1.207) b |
   Positive FSG | 1899 / 19,179 | 0.837 (0.796–0.879) b | 845 / 12,307 | 0.859 (0.797–0.926) b | 1054 / 6872 | 0.824 (0.771–0.881) b |
   Positive PSA | 108 / 568 | 1.402 (1.159–1.697) c | 37 / 337 | 1.055 (0.762–1.461)c | 71 / 231 | 1.684 (1.331–2.132) c |
   Positive DRE | 758 / 5312 | 1.030 (0.954–1.112)c | 310 / 3262 | 0.983 (0.873–1.108)c | 448 / 2050 | 1.062 (0.962–1.172)c |
   Positive CA-125 | 34 / 305 | 1.358 (0.969–1.905)d | 14 / 195 | 1.322 (0.780–2.239)d | 20 / 110 | 1.396 (0.898–2.170)d |
   Positive TVU | 451 / 6085 | 0.847 (0.768–0.935) d | 212 / 4086 | 0.847 (0.733–0.978) d | 239 / 1999 | 0.855 (0.747–0.978) d |