Fig. 4 | Scientific Reports

Fig. 4

From: Prediction of vancomycin plasma concentration in elderly patients based on multi-algorithm mining combined with population pharmacokinetics

Fig. 4

The model’s interpretation by SHAP. CL, clearance; TSLD, time since last dose; Cr, creatinine; UA, uric acid; Hgb, hemoglobin; SOFA, sequential organ failure assessment; Vd, volume of distribution; TP, total protein; ALT, alanine aminotransferase; Cys-C, cystatin C. (A) The SHAP summary plot of the top 16 relevant variables. The SHAP value (x-axis) is a unified index responding to the effect of a variable in the ensemble model. In each variable importance row, all patients’ attributes to the outcome were plotted using different colored dots, in which the red (blue) dots represent high (low) values. The higher the SHAP value of a variable, the higher vancomycin concentration. (B) The importance ranking of the top 16 variables according to the mean (|SHAP value|).

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