Fig. 6 | Scientific Reports

Fig. 6

From: CHD1L accelated the progression of cutaneous squamous cell carcinoma via promoting PI3K/PD-L1 signaling pathway induced M2 polarization of TAMs

Fig. 6

CHD1L promotes the expression of PD-L1 in cutaneous squamous cell carcinoma cells in a hypoxic environment and promotes M2 polarization in TAMs through exosomes. (A) p-PI3K, p-AKT, and PD-L1 protein bands and relative protein expression levels in A431 cells; (B) CD9, TSG101, and PD-L1 protein bands and protein expression levels in exosomes; (C) CD206, Arginase-1, iNOS, IL-1β, p-AKT, p-mTOR, VEGF, COX-2, MMP2, MMP9, and p-ERK1/2 protein bands and relative protein expression levels in tumor-associated macrophages. GAPDH as control protein; Data are expressed as mean ± standard deviation; N = 3; **P < 0.01.

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