Fig. 4

Effects of COS on fibroblast cell proliferation. (A–C) CCK-8 assay detecting fibroblast viability following treatment with 0–2 mg/ml COS for 24, 48, and 72 h; (D–L) EdU assay detecting cell proliferation following treatment with 0–2 mg/ml COS for 36 h; (M) Statistical analysis of (D–L). Scale bars, 200 μm in (D–L). Data are expressed as mean ± SEM from three independent experiments (*p < 0.05).