Table 2 Analysis for association between glucocorticoid use and outcomes.

From: Association of glucocorticoids with outcomes in critically ill patients with sepsis-associated acute kidney injury: a multicenter retrospective cohort study

 

ICU mortality

In-hospital mortality

Recovery of renal function

HR (95% CI)

P value

HR (95% CI)

P value

OR (95% CI)

P value

MIMIC-IV + eICU-CRD

 

Unadjusted model

1.39 (1.21, 1.60)

<0.01

1.30 (1.15, 1.47)

<0.01

0.84 (0.74, 0.96)

<0.01

Adjusted model 1

1.36 (1.18, 1.56)

<0.01

1.30 (1.15, 1.47)

<0.01

0.85 (0.75, 0.97)

0.02

Adjusted model 2

1.23 (1.07, 1.41)

<0.01

1.16 (1.02, 1.32)

0.02

0.98 (0.85, 1.13)

0.80

MIMIC-IV

 

Unadjusted model

1.45 (1.24, 1.69)

<0.01

1.38 (1.20, 1.60)

<0.01

0.86 (0.75, 0.99)

0.03

Adjusted model 1

1.41 (1.20, 1.65)

<0.01

1.38 (1.20, 1.60)

<0.01

0.88 (0.76, 1.01)

0.07

Adjusted model 2

1.26 (1.07, 1.47)

<0.01

1.20 (1.03, 1.38)

0.02

1.04 (0.89, 1.21)

0.60

eICU-CRD

 

Unadjusted model

1.48 (1.09, 2.03)

0.01

1.33 (1.03, 1.73)

0.03

0.63 (0.42, 0.95)

0.03

Adjusted model 1

1.50 (1.10, 2.05)

0.01

1.34 (1.03, 1.74)

0.03

0.64 (0.42, 0.97)

0.04

Adjusted model 2

1.29 (0.94, 1.78)

0.12

1.21 (0.93, 1.57)

0.16

0.64 (0.41, 1.00)

0.05

  1. Abbreviations: CI, confidence interval; eICU-CRD, the electronic Intensive Care Unit Collaborative Research Database; HR, hazard ratio; MIMIC, the Medical Information Mart for Intensive Care; OR, odds ratio.
  2. Model 1: Adjusted by gender, age, ethnicity.
  3. Model 2: Adjusted by gender, age, ethnicity, weight, vital signs, laboratory-based data, comorbidities, SOFA, GCS score, treatment information.
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