Fig. 3
From: MSC-EVs and UCB-EVs promote skin wound healing and spatial transcriptome analysis
MSC-EVs and UCB-EVs promote skin wound healing in mice. (A) Gross views of wounds treated with MSC-EVs, UCB-EVs, or PBS on days 0, 3, 7, 11, 15, and 17 post-injury. (B) Wound healing rates in different treatment groups. Each group contains n = 6. (C) HE staining of wound sections treated with MSC-EVs, UCB-EVs, or PBS 17 days after surgery. The black arrow indicates the edge of the scar. Scale: 500 μm. (D) Masson’s trichrome olor staining of wound sections treated with MSC-EVs, UCB-EVs, or PBS. (E) Quantitative analysis of the scar width and degree of re-epithelialization. Each group contains n = 3. (F) qRT-PCR was used to detect the mRNA expression of scarring-related factors and collagen after co-culture of MSC-EVs and UCB-EVs with HDF-a. (G) qRT-PCR was used to detect the mRNA expression of scarring-related factors and collagen in wound tissue of mice on day 17 after treatment. *P < 0.05, **P < 0.01, ***P < 0.001.
