Fig. 7 | Scientific Reports

Fig. 7

From: Peripheral nerve regeneration using a bioresorbable silk fibroin-based artificial nerve conduit fabricated via a novel freeze–thaw process

Fig. 7

Promotion of vascularization and macrophage-related immune response after transplantation. The SFC group showed a higher degree of vascularization and M2 macrophage recruitment than the other groups. (A) Representative images of the NC, SFC, Auto, and Sham groups observed using light microscopy, showing the area around the regenerated nerves, immunostained for CD31. (B) The total CD31-positive area of the SFC group was greater than that of the other groups, indicating that the SFC promoted vascularization inside the conduit. (C) Representative images of the NC, SFC, Auto, and Sham groups observed using light microscopy, showing the area around and inside the regenerated nerves, immunostained for Iba1 and arginase-1. (D) The total Iba-1 and arginase-1 double-positive area of the SFC group was greater than that of the other groups, indicating that the SFC promoted M2 macrophage recruitment.

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