Table 1 Patient characteristics at baseline, overall, and by disease severity at randomization, in DisCoVeRy.
From: sST2 is a key outcome biomarker in COVID-19: insights from discovery randomized trial
Characteristic | N | Overall, N = 454 | Disease severity at randomization | p-value | |
|---|---|---|---|---|---|
Moderate, N = 309 | Severe, N = 145 | ||||
Age, years | 454 | 63 (54, 71) | 63 (53, 72) | 64 (56, 71) | 0.52 |
Sex male | 454 | 323 (71%) | 217 (70) | 106 (73%) | 0.53 |
BMI, kg/m2 | 398 | 27.7 (25.2, 32.0) | 27.2 (25.0, 31.2) | 28.7 (26.0, 34.4) | 0.007 |
Days from symptoms onset to randomization | 451 | 9.0 (7.0, 12.0) | 9.0 (7.0, 12.0) | 9.0 (7.0, 12.0) | 0.78 |
Ventilatory support at randomization | 454 | < 10−6 | |||
Room air | 32 (7%) | 30 (10%) | 2 (1%) | ||
Oxygen support | 331 (73%) | 275 (89%) | 56 (39%) | ||
Invasive Mechanical Ventilation | 91 (20%) | 4 (1%) | 87 (60%) | ||
WHO 7-points ordinal scale at baseline | 454 | < 10−6 | |||
(3) Hospitalized, not requiring supplemental oxygen | 11 (2%) | 11 (4%) | 0 (0%) | ||
(4) Hospitalized, requiring supplemental oxygen | 295 (65%) | 281 (91%) | 14 (10%) | ||
(5) Hospitalized, on non-invasive ventilation or high flow oxygen devices | 46 (10%) | 11 (4%) | 35 (24%) | ||
(6) Hospitalized, on invasive mechanical ventilation or ECMO | 102 (22%) | 6 (2%) | 96 (66%) | ||
ISARIC 4C score (continuous)a | 454 | 11 (9, 13) | 10 (8, 12) | 12 (10, 14) | < 10−3 |
ISARIC 4C score (categorical)a | 454 | 0.002 | |||
Low: [0,3] | 4 (0.9%) | 4 (1.3%) | 0 (0%) | ||
Intermediate: (3,8] | 105 (23%) | 83 (27%) | 22 (15%) | ||
High: (8,14] | 303 (67%) | 201 (65%) | 102 (70%) | ||
Very High: (14,21] | 42 (9.3%) | 21 (6.8%) | 21 (14%) | ||
NEWS2 score at baseline | 454 | 9 (7, 12) | 8 (6, 10) | 12 (10, 15) | < 10−6 |
NEWS2 score at day 15 | 454 | 5 (2, 10) | 3 (1, 6) | 11 (7, 14) | < 10−6 |
Change in NEWS2 from baseline to day 15 | 454 | − 4 (− 7, 0) | − 4 (− 7, − 2) | − 2 (− 5, 2) | < 10−4 |
Discharged from hospital at day 29b | 454 | 65.2% [61.0%–69.8%] | 81.2% [76.9%–85.7%] | 31.7% [25.0%–40.3%] | < 10−15 |
Number of deaths by day 29 | 454 | 25 (6%) | 15 (5%) | 10 (7%) | 0.37 |
