Table 2 Association between non-alcoholic fatty liver disease and the risk for young-onset ovarian cancer.

From: Increased risk of young-onset ovarian cancer in women with non-alcoholic fatty liver disease: A nationwide cohort study of 2.3 million women aged 20–39 years

NAFLD

N

Event, n

Person-years

IR*

HR (95% CI)

Model 1

Model 2

Model 3

Model 4

No

2,239,752

5,694

25,260,868

22.5

1 [Reference]

1 [Reference]

1 [Reference]

1 [Reference]

Yes

136,730

625

1,525,633

41.0

1.84 (1.69–2.00)

1.62 (1.50–1.76)

1.30 (1.16–1.45)

1.30 (1.16–1.45)

Moderate

95,156

406

1,064,675

38.1

1.71 (1.54–1.89)

1.49 (1.35–1.65)

1.26 (1.12–1.42)

1.26 (1.12–1.41)

Severe

41,574

219

460,959

47.5

2.15 (1.88–2.46)

1.95 (1.70–2.23)

1.45 (1.22–1.72)

1.45 (1.22–1.72)

  1. *Incidence rate per 100,000 person-years.
  2. Model 1: Unadjusted.
  3. Model 2: Adjusted for age (continuous).
  4. Model 3: Additionally adjusted for smoking status, alcohol consumption, physical activity, body mass index, and diabetes.
  5. Model 4: Additionally adjusted for pelvic inflammatory disease, endometriosis, polycystic ovary syndrome, and tubal ligation.
  6. CI, confidence interval; HR, hazard ratio; IR, incidence rate; NAFLD, non-alcoholic fatty liver disease.
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