Extended Data Fig. 1: Changes in de novo NAD+ synthesis pathway in human and mouse kidneys.
From: NAD+ precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury
a, Simplified de novo NAD+ synthesis pathway. The colour indicates metabolites significantly higher (red) or lower (blue) in injured kidneys of human and mice. b, Relative quantification of tryptophan, kynurenine, and quinolinate in human kidneys (Healthy control n = 25. KD n = 25). *P < 0.05. NS, not significant. c, Relative quantification of tryptophan, kynurenine, and quinolinate in mouse kidneys (PBS n = 4. Cis n = 4). **P < 0.01, ***P < 0.001. d, Heatmap showing the expression of genes involved in NAD+ metabolism in human kidneys. Color indicates higher (red) or lower (blue) expression. e, Heatmap showing the expression of genes involved in NAD+ metabolism in mouse kidneys. Color indicates higher (red) or lower (blue) expression. Data are presented as mean ± s.e.m. and were analysed using a two-tailed Student’s t-test.
