Fig. 2: Risk of depression according to genetic risk and lifestyle.

We utilized 197,344 participants with both PRS and lifestyle scores in the analyses. The results were adjusted for age, sex, Townsend deprivation index, BMI and education level. Two-sided unadjusted association P values from multivariate Cox models are given. Individuals with high risk for depression and unfavorable lifestyle were used as the reference category. Data are presented as mean values ± s.e.m. The widths of the lines extending from the center points represent 95% CI.