Volume 3 Issue 6, June 2025

The Trump Administration’s executive orders that target diversity, equity and inclusion initiatives, humanitarian approaches to migration management, and climate justice policies threaten the core ethical principle of ‘do no harm’ and make it harder to account for and respond to the violence and mental health consequences of the USAID Stop Work Order.

A comprehensive appraisal of community, academic and grassroots efforts to address anti-Asian discrimination reveals that public health research has focused on individual-level mental health impacts. Collectively, the research community should focus on asset-based approaches to prevent discrimination and address its mental, physical, and socioeconomic effects on Asian American communities.

Mental disorders among young people are rising in incidence and severity, yet access to effective treatment is limited. This Comment presents leading international mental health policies that could be adapted and applied in the USA through an integrated, three-tiered prevention approach.

One in three stroke survivors experience depression or anxiety, but no large-scale studies of real-world clinical practice have assessed whether psychological therapies are beneficial for these patients. We analyzed national healthcare records in England to evaluate the effectiveness of primary care psychological therapies for stroke survivors with common mental disorders.

Genetic variants and regions associated with cannabis use disorder (CanUD) and cannabis use also influence a range of psychiatric traits. We used genetic methods to demonstrate increased risk caused by CanUD of developing several psychiatric disorders, and that psychiatric disorders also increase CanUD risk. There were genetic differences between cannabis use and CanUD.

In this Perspective, the authors cover what is known about anxiety and depression symptoms and sleep disturbance in relation to Alzheimer disease pathology and cognitive decline.

In this study, authors explore cortical morphology using Mendelian randomization to identify positive causal effects of total brain cortical surface on neuropsychiatric phenotypes.

This study investigates the effectiveness of psychological therapies for depression and anxiety symptoms in 7,597 stroke survivors within England’s primary care system. Results show that 71.3% of stroke survivors experienced reliable improvement and significant reductions in symptom scores, underscoring the importance of intervention for improving recovery.

The Global Flourishing Study provides a comprehensive view of the distribution and determinants of well-being by assessing domains such as health, happiness, meaning, character, relationships and financial security. Initial findings reveal significant variations in flourishing across countries and demographic groups, with factors such as age, marital status and religious service attendance showing strong associations with well-being.

Reinforcement learning task-based behavioral and computational measures displayed low test–retest reliability at the individual level. Also in contrast to self-assessed personality measures, behavioral and computational measures were poor predictors of mental health measures, representing a challenge for computational psychiatry.

Chronic loneliness and isolation significantly increase risks of functional impairment and mortality, as shown through longitudinal analysis of 5,131 participants using Cox proportional hazards and Fine–Gray models, highlighting the importance of addressing these social deficits in older adults.

This study addresses variations in suicide rates across the United States and the impact of three county-level clusters of social determinants of health characteristics. The authors used unsupervised machine learning to analyze data from 2009 to 2019, revealing that remote areas, characterized by rurality and older populations, had the highest suicide rates, highlighting the need for addressing disparities with targeted interventions.

This study analyzes associations between sociodemographic factors, treatment intentions and mental health among transgender individuals. Utilizing multivariate regression, findings reveal distinct mental health challenges across treatment groups, emphasizing the necessity for personalized approaches in gender-affirming care.

This genetic study utilizing the newest available GWAS summary statistics provides evidence on the relationship between cannabis use, cannabis use disorder and a range of psychiatric disorders.

A comparison of functional connectivity patterns linked to autism and attention-deficit/hyperactivity disorder traits in children and adolescents reveals distinct patterns of brain connectivity despite frequent co-occurrence of these conditions.

The authors analyze white matter alterations in bipolar II depression, revealing significant correlations with inflammation and psychiatric symptoms. These findings suggest that childhood emotional maltreatment may exacerbate these effects and offer insights into potential therapeutic targets.

Cognitive behavioral therapy (CBT) is increasingly recognized for its potential to improve antiretroviral therapy adherence among people living with HIV. Here the authors conduct a systematic review and meta-analysis, revealing that CBT significantly enhances adherence, especially in individuals with psychiatric comorbidities and in low- and middle-income countries, although effects on viral metrics remain unclear.